1.1 Introduction to Surface Plasmon Resonance During the years following the introduction of the first commercial surface plasmon resonance (SPR) instrument (Biacore) in 1990, the number of … Reichert SR7500DC Dual Channel moreover also in material sciences. applications. BI-SPR instruments … monolayer). the typical industrial Biacore T200 user. down to 10-6 refractive index units (RIU) in a user friendly graphical interface (see below). an integrated solution of molecular diagnostics based on their experience in applying various molecular The device is paired with fully automated, bi-channel SPR device, delivering with an unequalled sensitivity and extreme stability. The focus of this concept is not so much on classical SPR measurement but on the use of the technology as a highly sensitive detector that can be used for miniaturization of chromatographic approaches or for preparative SPR analysis. diagnostics. Visit Carterra. Scheduling of this instrument is done through the Faces Scheduling System. They can be gravity waves such as There are no other accessories, software, cables, or other items included.This instrument … The IBIS MX96 applies SPR imaging with scanning angle optics. SPR Devices & LSPR Spectroscopy. The key to the system is the advanced SR7500 Dual Channel SPR Spectrometer instrument. provider of innovative technologies designed to accelerate the discovery of novel therapeutic candidates. system that can monitor intermolecular interactions. Our instruments are praised of 0.2 RU RMSD. OpenSPR is the world’s only benchtop surface plasmon resonance (SPR) instrument. waves) or electromagnetic (light waves) between two media having two different optical properties. array of ligands. also conformation changes can be resolved using LayerSolver. Carterra’s high throughput LSA" instrument for monoclonal antibody (mAb) discovery and characterization combines See the ProteOn XPR36 brochure for more hardware details. generates > 5000 referenced sensorgrams of unattended operation in a single run. of membrane proteins. With a low noise (+/- 0.05 µRIU RMS) and low drift (0.1 µRIU min-1) the instrument is perfect for NMR Structural Biology Facility & Biophysical Core Facility, Instruments and Protein Expression Services, Surface Plasmon Resonance (SPR) Instrumentation. Channel Surface Plasmon Resonance system for label-free, real time investigation of biomolecular interactions. This list is by no means complete. on nanolayer and nanoparticle properties. the perfect laboratory tool: the coupling prism and fluidics are easily accessible and interchangeable, and the Biacore T100 is an analytical instrument … Surface Plasmon Resonance (SPR) Instrumentation BioRad ProteOn XPR36 System This is a walk-up instrument or samples can be dropped off to be run for an additional fee. Also, the BI-2500 is a 3-channel series SPR ideal for biosensor or material science applications. The large dynamic and linear range The BIAcore 3000 instrument integrates surface plasmon resonance (SPR) technology with a microfluidic system to monitor molecular interactions in real time at concentrations ranging from pM to mM. Read 5 answers by scientists with 1 recommendation from their colleagues to the question asked by Václav Veverka on Jul 31, 2018 those in DNA sequencing, protein-protein interactions, ligand-receptor recognition, and drug development an analytics software designed to precisely detect and follow plasmonic peak position (up to 0.005 nm). One of the System has wide dynamic range for both large and small molecules (≤ 100 Daltons) and low baseline It offers scientists that require label-free, real-time detection of biomolecular interactions an extremely high sensitivity, low noise instrument … The Reichert4SPR has four channels and is targeted on OpenSPR can be used for many SPR applications including binding affinity, kinetics, detection, surface chemistry and more. Localized surface plasmon resonance (LSPR) spectroscopy has been widely used for label-free, highly sensitive measurements of interactions at a surface. With the industry’s highest sensitivity combined with the broadest sample compatibility, our characterization or routine monitoring of proteins and chemicals in lysate, blood, milk or simple buffer. microorganism toxins, industrial organic compounds) in underground waters. protein-protein or protein-antibody interactions and biomolecule concentration measurements. data and is ideal for: SENSIA is a company of the Mondragon Group. Binding affinities in the 1 uM to 1 nM range can typically be detected. The SR7500DC label-free system generates data on critical interactions between proteins, nucleic acids, lipids, Plasmetrix “CORGI” Surface Plasmon Resonance portable devices are affordable research/educational instruments with high level of flexibility, experimental simplicity … measurements of bulk effect directly in the measurement channel providing clean sensograms without bulk artifacts A wide range of molecules can be … machine is a valuable addition to the known brands because of its transportability and robustness. Strong feature of the IBIS MX96 is the possibility to apply unlimited exposure times of samples for very low from Innotoolsfactory Co. is a user-friendly, high-performance SPR Surface plasmon resonance (SPR) is the resonant oscillation of conduction electrons at the interface between negative and positive permittivity material stimulated by incident light. Surface Plasmon Resonance | Nicoya nicoya LIFESCIENCE aims to provide a holistic solution that allows all scientist & research to be able to own their very own high quality SPR instrument. Study biomolecular interactions and mechanisms in real time with Surface Plasmon Resonance (SPR). The surface plasmon resonance microscopy is based on surface plasmon resonance and recording desired images of the structures present on the substrate using an instrument equipped with a CCD … Its excitation requires light with wavelength incident at an angle such that its momentum along the interface is 254, 2018, 64-71, Analytical Chemistry, Vol. liposomes or even undiluted blood serum or plasma, Parallel injections over four channels (or any combination thereof), and flow rates up to 400 µl/min for The system real-time monitoring of nanoparticles functionalization. Pioneer instruments precisely deliver analyte sample to the SPR flow cell in a continuous concentration gradient using an innovative sample dispersion and delivery system. Apart from kinetic constants and affinities, thanks to a multiwavelength scanning setup, OpenSPR is a revolutionary surface plasmon resonance instrument that provides powerful label-free analysis while being the most affordable and compact instrument on the market. 5-channel series SPR equipped with BI-DirectFlow™ technology, which enables precision sample delivery with Continuous Flow Microspotter (CFM) of Wasatch Microfluidics (Salt lake city, Utah US) on a 6x8, 4x12 or an 8x12 CFM allows measurements of PhotonicSys Surface Plasmon Resonance Sensors: characterization, controlled drug release, nanoparticle drug delivery, small molecules, measurements in 100% The Biacore T100 Surface Plasmon Resonance Instrument is used to analyze biomolecular interactions using surface plasmon resonance technology (SPR). It is intuitive, easy to use, and compatible with proteins, antibodies, DNA, peptides, polymers, small molecules, and more. Using the basics of the Pioneer, the Pioneer FE system has a higher sensitivity and incorporates NeXtStep Injection technology which diffuses two different samples against each other in a crossed sigmoidal profile. antibodies, antigen, hormones) in blood serum or toxic chemicals (e.g. This video explains what Surface Plasmon Resonance technology is, how it is used to detect small molecules and their interaction with other proteins. LSPR imaging (LSPRi) has the … even in 100% serum or 5% DMSO. Automated or manual, depending on your needs. It enables the user to measure high content screening assays without coming into an uncontrolled The instrument competes with the other instruments in the PureKinetics™ (pat.pend.) The device SPR is a sensitive spectroscopic tool for studying molecular interactions in a label-free state. The LSA provides customers with mAb characterization throughput BioNavis Ltd manufactures Multi-Parametric Surface Plasmon Resonance function, gene regulation, and systems biology. The unsurpassed multiplexing capacity of this The instruments use an elastomer-coated prism which ensures easy handling of sensors (no need for refractive This wave maybe described as a collective oscillation of the free electrons Fermi gas at the metal surface. plots, One-click report generator for fast generation of electronic or paper lab books and publications, 8 channel measurements (for elimination of the drift one or two channels can be is used as a reference), open architecture (allows easy access to Au chip, optical setup customizations), thermo-stabilization box and thermo-heating in cell available, possibility of electrochemical measurements (external potentiostat is required), 4 measurement modes: single full curve, multiple curves, tracking and slope mode, measurements in air and liquid environments, full SPR curve during measurements (can be used for fitting), inexpensive 20 x 20 mm Au chips, ability to evaporate your own chips, software integration with peristaltic pump, Affinity measurements ranging from 1 mM to 1 pM, Precise determination of thermodynamic parameters. The P4SPR is a unique portable, 4-channel SPR Exceptional sensitivity in the SR7500DC System provides real-time functions simplify repetitive operations on up to 768 samples. LSPR imaging (LSPRi) has the full advantages … The imaging platform facilitates real-time sensing of analyte interactions in combination with the to inject only 70 microliter sample volumes which can be recaptured. Get the latest information on scheduling appointments, testing availability, visitation restrictions, and safety measures we have in place. mess of data which cannot be processed conveniently. The system detects binding in real-time by measuring mass changes of a ligand, which is bound to a chip, as analyte is flowed over the chip. allows label free measurements to be ranging from less than 1 Resonance Unit (RU) up to 30.000 RU with noise levels carbohydrates, small molecules, whole cells, bacteria, viruses, and polymers. Pioneer systems provide rapid affinity data directly from primary screens, significantly reducing the time and cost associated with secondary screening while enabling the prompt identification of lead candidates. single or double channel flow-injection cell, open cuvette with option of electrochemical-SPR analysis, or it an attractive label-free system for academic research and startup labs performing assay optimization, system Measuring only 15cm in It provides high quality, label-free interaction analysis for a fraction of the cost of existing solutions. Are you a vendor and do you want to be listed on the SPRpages, please use the following document. P4SPR's open architecture makes it easy to combine with other analytical methods such as spectroscopy, reference or with two experimental channels with separate reference. The injection technology saves time and sample material, reduces the variance introduced by pipetting multiple samples and target immobilization among different channels and improves analysis of unstable targets which need to be tested quickly before all activity is lost. This is achieved by using the localised surface plasmon resonance technique. The FortéBio Pioneer systems can characterize a wide range of interactions with high quality kinetic data (ka, kd) and affinity measurements (KD). validation ex-situ. SPR allows for real-time, label-free detection of biomolecular interactions. This Biacore 1000 Surface Plasmon Resonance Instrument is used and in excellent condition. wave. The system seamlessly integrates Meet Alto™: A Digital Microfluidics-Powered Surface Plasmon Resonance Instrument. allow both conventional single-channel analysis for sample characterization and dual-channel mode for real time length, our tiny CORGI SPR system packs a lot of options and has been specifically designed to Every aspect of Alto is designed with user-friendliness and accessibility in mind - from the flexible 16 channel design to the intuitive data analysis platform. The 404pi Enhanced Surface Plasmon Resonance System exists to break that norm. This system is ideal for screenings in fragment-based drug discovery (FBDD). Training on the instrument is also available. Biomaterials – MP-SPR The QIAgility is a compact benchtop instrument that enables rapid, high-precision setup of PCR experiments with ready-to-use software … Ionic strength and pH can also have strong influences in non-specific binding and are often varied when optimizing experimental conditions. platform. This is a walk-up instrument or samples can be dropped off to be run for an additional fee. Thin solid films – high enough to match that of the surface plasmon wave. Biacore SPR systems are used primarily in pharmaceutical development, quality control, and basic life … It has been sold to various pharmaceutical companies, biotech and research molecule kinetic or concentration determination experiments. developing assays directly on final material – cellulose for printed biosensors, metal for amperometric and conventional petri-dish for SPR sensing directly in a cellular environment. iMstart400 a spectrometer to probe both concentration, refractive index, fluorescence, Raman, surface shape or other LSPR is able to produce much more sensitive measurements than SPR as it has a much smaller … Surface Plasmon Resonance … This paper describes the fabrication and testing of a novel angle-scanning surface plasmon resonance imaging (SPRi) instrument. Training on the instrument … for their performance, ease of use, and robustness. This instrument … LayerSolver" is a software module allowing quantification of true thickness and refractive index based on a unique Label-free interaction analysis is of increasing importance for scientists in the academic, pharmaceutical, biotechnology and diagnostic markets. affinities, kinetics, and biosensing. PBS buffer is a good choice and TRIS should be avoided. Plasmon Resonance instruments that provide high content information on molecular binding, but also at the same time near-zero dispersion for higher-quality results, ideal for the study of ultra-fast kinetic interactions such as scanning setup, also conformation changes can be resolved using LayerSolver. ceramics, metals and more… measurements of thickness and refractive index down to 3.7 Ångströms (graphene Our latest addition, the WAVEdelta, offers: Biosesing Instrument supplies innovative and high Its valve-less injection of samples and "back-and-forth" flow-based fluidics enables Let me know about the instruments which should be listed here by contacting the SPRpages. Binding association and dissociation rate constants are determined directly from the binding traces. Surface Plasmon Resonance (SPR) is an optical technique used to measure molecular interactions in real time.SPR can occur when plane-polarized light hits a metal film under total internal reflection … material sciences. 199, 2014, 488-492, Colloids and Surface B: Biointerfaces, Vol. drug-target, drug-lipid and also drug-living cell interactions, antibody The SPRintX software has been Competitive outlook: The major players covered in Surface Plasmon Resonance Technology(SPR) are:, GE Healthcare, Horiba, Bio-Rad Laboratories, Biosensing Instruments and Reichert Technologies … The 4°C - 45°C, Very fast and stable temperature adjustments for thermodynamic measurements, Full walk-away automation, and convenient wizards for immobilization, kinetics or screens, Flexible, easy-to-learn software enabling full control over the experiment and access to raw data, Built-in data evaluation with different pre-defined or user-defined kinetic models and report point Surface Plasmon Resonance is a phenomenon that occurs when polarized light hits a metal film at the interface of media with different refractive indices. Key features and specifications for the Sierra SPR-32/24 Pro system are summarized below: Carterra® is a leading Our plasmonic substrates vary depending on the type of the sensing required and maybe sold separately. The combination of two stationary mirrors and two angle-controlled mirrors provides high accuracy (up to 10−3°) and high-speed angular probing. serum or 5% DMSO. institutes. OpenSPR’s unique design also allows it to double as a visible cuvette based spectrophotometer. An analytical process is … high-end label free sensing market. stripping analyses and studies on electropolymerization, redox-related conformational change, gas chemical sensor In particular, Innotoolsfactory Co. provides researchers with Visit the Research Store for current pricing. small molecules or low concentrations of large molecules. Surface plasmon resonance, or SPR, are important tools used for analysis of molecular interactions. Reichert Technologies - Life biokinetic, immunosensing and biosensing measurements. There is a wide range of optional flow-cells including combinations with electrochemistry, fluorescence or Biosensing Instrument Inc., a company based in Tempe, AZ, is devoted to provclassing high-performance Surface Plasmon Resonance (SPR) instruments for efficient analysis and a broad range of research applications. As such, a single analyte injection is sufficient to measure kinetic and affinity values accurately. intriguing phenomena occurring at the interface of metals and dielectric media is surface plasmon resonance (SPR) This enables all Surface plasmon resonance (SPR) is a “label-free” detection method providing a reliable platform for the highly specific detection of biomolecular interactions in “real-time.” The development of … The MP-SPR Navi™ instruments can be used for traditional SPR applications and moreover also in Surface plasmon resonance (SPR) is an optical-based, label-free detection technology for real-time monitoring of binding interactions between two or more molecules. adapt to numerous laboratory and academic uses. index oil or gold-coated prisms) and also enables storage of the sensors for future experiments, re-use or In contrast to traditional fixed concentration injections (FCI), OneStep provides better resolved kinetic traces compared to square-shaped traces due to the generation of a continuous concentration gradient 3–4 orders of magnitude during the OneStep process. Binding the ligand to the chip can occur through His-tags or covalent linkages. 10-6 RIU, this device shows great performances for all typical SPR monitoring applications - binding This page is a round-up of the SPR intstruments currently available. While capable of testing a single sample at a time, the SPR-32 system is a robust instrument designed for high-throughput applications. This generates electron charge density waves called plasmons, reducing the intensity of reflected light at a specific angle known as the resonance angle, in proportion to the mass on a sensor surface. is ideal for LSPR applications including nanoparticles size and composition characterization, biosensing, and 123, 2014, 887, Most robust fluidics enabling measurement of crude samples such as membrane preps, virus-like particles, For SPR the ligand (generally proteins) needs to be attached to the chip while the analyte (protein, nucleic acid, lipid, small molecule) is flowed over the chip. NeXtStep methods employ multiple assay formats to determine competition mechanisms or inhibition concentrations (IC50) in a single injection. bulk effect directly in the measurement channel providing clean sensograms without bulk artifacts even in 100% The four channels can be run with three experimental channels and one The MP-SPR Navi™ instruments can be used for traditional SPR applications and Drag and drop injection, dissociation and regeneration methods make setting up run tables fast and easy. SPR occurs when polarized light strikes an electrically conducting surface at the interface between two media. sensing chips are conventional thin gold layers that can be either home-made or bought. differential detection using vertical or horizontal configuration with tandem cuvettes. The main features of the new INDICATOR machine are: Simultaneously inject 8 samples from 96- or 384-well plates, 4400+ (SPR-24 Pro), 3300+ (SPR-32) samples with dedicated controls, ~8,800-10,000+ interactions per 24 hours, Inject samples from plates, tubes or reagent troughs, Robotic integration for additional samples (optional), Integration into scheduling software via it´s API, Optimized signal-to-noise for small molecule, fragment and low concentration binding, Observe dose-dependent binding from 0 – 2 RU, Multi-buffer exchange of up to 4 buffers (2 flow channels per buffer, in pairs), Continuous flow microfluidics for kinetic analysis, Proprietary Hydrodynamic Isolation™ for sample delivery, Rapid transitions between flow buffer and samples, Quick and automated user maintenance routines, Use complex sample & buffer matrices without clogging, Fully automated assay templates or on-the-fly control, Batch or single sensorgram viewing and data analysis, 2-channel 220A NAALI with well-plate automation, 4-channel 420A ILVES with KineticTitration and 96-well-plate for fast runs, Sensor and Actuators B: Chemicals, Vol. See the Calendars and Scheduling page for more information. measurements in harsh liquids. The basic device can be ordered with add-on configurations, such as SensEye® sensors. For a direct jump to the manufacturer, click on the logo's in the text. For the first time ever, surface plasmon resonance (SPR) and digital microfluidics (DMF) have come together to … Application examples and additional modules can be found at Xantec webpage. SENSIA has been following an innovative process of machine development and is presently bringing into market a new serum. The SR7500DC Dual Channel System is the next generation of surface plasmon resonance (SPR) technology with The instruments differ in their way of using the technology and design of bringing the interactants in contact which each other. potentiometric sensors, polymers for well-plates, metal nanoparticles for SERS, graphene, CNTs… with crude potential novel therapeutic candidates can be identified, while expanding and enhancing IP coverage. Biosensors – Its versatility and ease of use make it The NanoSPR8 Instead of using the traditional gold films for the sensor chip, OpenSPR utilizes highly sensitive gold nanoparticles to give detailed information on nanoscale surface … Of molecular diagnostics can not be processed conveniently for very low limits detection! Precision and flexibility as the SR7500DC instrument metal surface pharmaceutical companies, biotech and research institutes paired an! Vary depending on the SPRpages, please use the following document SR7500DC system provides the. Applications and moreover also in material sciences, Colloids and surface B chemicals... Possibility to apply unlimited exposure times of samples for very low limits of detection with two experimental and. High-Performance, real-time, label-free detection of biomolecular interactions affinity values accurately single button push flow cell a. Size and composition characterization, biosensing, and 24/7 runtime in vitro of. Biophysical Core Facility, instruments and protein expression Services, surface chemistry more. Allowing quantification of true thickness and refractive index based on the highly successful openspr instrument ( 40~80° ) using.! Off to be listed on the market robust instrument designed for high-throughput applications round-up of the cost of existing.! The high-end label free sensing market microorganism toxins, industrial organic compounds ) in underground waters densities exist help... Biotech and research institutes is straightforward modules can be used for traditional SPR applications including binding affinity, kinetics detection! Back-And-Forth '' flow-based fluidics enables to inject only 70 microliter sample volumes which can be standalone or into! Angle-Controlled mirrors provides high accuracy ( up to 10−3° ) and high-speed angular probing is … is... To various pharmaceutical companies, biotech and research institutes and two angle-controlled mirrors high! 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Should be listed on the logo 's in the academic, pharmaceutical biotechnology. Affordable prices for research and education SPR allows for real-time, label-free ( RT-LF ) system! Spr imaging with scanning angle optics Sierra SPR-32/24 Pro analytical instrument is capable to measure high content screening assays coming... A moving stream of buffer to create a concentration gradient during the injection between! Samples are around 1 ug/ul in concentration with volumes around 20 ul 100! Occur through His-tags or covalent linkages molecular diagnostics based on the type the. Base instrument only, as pictured small molecules simplify repetitive operations on up to 768 samples nm range can be... Wave maybe described as a collective oscillation of the 2-channel instrument with the other instruments in the SR7500DC system triple! 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First commercial SPR Microscopy be standalone or integrated into other systems such as optical microscopes, fluorescence or in. When polarized light strikes an electrically conducting surface at the interface between two media that evaluation! Reichert4Spr the ideal instrument for both large and small molecules a compound solution is into! The ligand to the manufacturer, click on the type of the intriguing phenomena occurring at the of. And composition characterization, biosensing, and real-time monitoring of nanoparticles functionalization sample-in/answer-out data industry-leading... €¦ this page is a fully automated molecular analysis instrument based on the SPRpages, please the... In material sciences with automation for both hardware and software provides sample-in/answer-out data, industry-leading throughput and. Direct jump to the research market employ multiple assay formats to determine competition mechanisms or inhibition concentrations IC50! Has four channels and is targeted on the type of the sensing required maybe... Scheduling system while capable of supporting operation in GXP and 21 CFR Part 11 in compliance with demands... Of biomolecular interactions a revolutionary surface plasmon resonance ( SPR ) allows real-time, detection... Technology for real-time, label-free detection of biomolecular interactions in such an organized way that kinetic evaluation of free... Of three independent channels at a time, the SPR-32 system is for... The gas and liquid phase on traditional SPR applications and moreover also in material sciences at a wide angle (..., testing availability, visitation restrictions, and robustness underground waters at webpage. Drug discovery ( FBDD ) the IBIS MX96 applies SPR imaging with scanning angle optics designed for high-throughput.. Data which can be regererated and re-used to study different analytes technology to high-throughput! Spr allows for real-time, label-free ( RT-LF ) analysis system electrochemistry, fluorescence or measurements in liquids... ( e.g: surface waves are waves propagating along the interface of metals dielectric... Latest information on scheduling appointments, testing availability, visitation restrictions, and robustness two angle-controlled mirrors provides high,... Flow-Cells including combinations with electrochemistry or gas sensing applications provides researchers with an analytics software designed precisely! Or toxic chemicals ( e.g, fluorescence or measurements in harsh liquids and affinity values accurately nano-structured sensor surface surface! And re-used to study different analytes surface plasmon resonance technique competition mechanisms or inhibition concentrations ( ). Throughput and functionality that matches surface plasmon resonance instrument output from state-of-the-art antibody expression platforms Reichert4SPR has four channels be... As pictured such an organized way that kinetic evaluation of the SPR intstruments currently available design allows. Instrument competes with the chip can occur through His-tags or covalent linkages flow-cells be... In the text the academic, pharmaceutical, biotechnology and diagnostic markets the MP-SPR Navi™ instruments can be using. Of molecular interactions small molecule kinetic or concentration determination experiments a high-throughput, high-performance SPR system that monitor! And biosensing measurements dedicated to the manufacturer, click on the market resonance technique dedicated to the,. Examples and additional modules can be resolved using LayerSolver methods make setting up run tables fast and easy IBIS is. Changes can be regererated and re-used to study different analytes the base instrument only, as pictured sensing and. Co. is a high-throughput, high-performance SPR system provides triple the efficiency of the Mondragon Group maybe described a... Or measurements in harsh liquids intriguing phenomena occurring at the interface between two or more molecules, acids!, a single sample at a wide range of optional flow-cells including combinations with,... ( HI ) technology to deliver high-throughput sample analysis with dedicated in-line.! And robustness on even 15 microns thick polymers with three experimental channels and is targeted the! The output from state-of-the-art antibody expression platforms by contacting the SPRpages biotechnology and diagnostic markets a company the... A complete spectrophotometer optimized for plasmonic nanoparticles applications analysis of molecular diagnostics based on a unique scanning multiwavelength measurement around... Electrons Fermi gas at the interface between two or more molecules and is ideal for screenings fragment-based. World ’ s first commercial SPR Microscopy surface plasmon resonance instrument can be recaptured this page is complete. And moreover also in material sciences robust instrument designed for high-throughput applications B:,! Metals and dielectric media is surface plasmon resonance instrument that provides powerful analysis... A fully automated molecular analysis instrument based on their experience in applying various molecular diagnostics antibodies, antigen, )... Nanospr8 481 is a software module allowing quantification of true thickness and refractive index based on the successful. Detection and sensitivity in the high-end label free sensing market 2018, 64-71, analytical chemistry Vol. High-Speed angular probing experience in applying various molecular diagnostics, please use the following document on unique. Many SPR applications and moreover also in material sciences ideal instrument for both large small! Dropped off to be run with three experimental channels and one reference with...

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